Outcomes of Conventional Root Canal Treatment Compared to Regenerative Endodontics, and Cleaning and Shaping Only in Mature Upper First Premolars

Ain Shams University

Status: Completed

Conditions: Regenerative Endodontic Treatment; Necrotic Mature First Premolar; Cleaning and Shaping Only With Proper Coronal Seal

Treatments: Procedure: Cleaning and shaping only; Other: cell homing

Study type: Interventional

Funder types: Other

Identifiers

NCT07609732

28/2/1993

Details and patient eligibility

About

It was to compare clinically between the success of the primary endodontic treatment, regeneration, and only cleaning and shaping in necrotic mature first premolars with apical periodontitis

Full description

a- Fifty four patients were enrolled and screened for eligibility b- Participants were randomly assigned to three groups (n=18 per group) i- Group [CRCT]: Conventional root canal treatment (n=18) ii- Group [REP] : Regenerative endodontic treatment (REP) (n=18), cell homing technique was used , and MTA was placed 3mm into the canals , the access was sealed by light cured glass ionomer then composite iii- Group [C.S]: Only cleaning and shaping (n=18) the same steps of REP but without bleeding induction and MTA was placed 3mm into the canals , the access was sealed by light cured glass ionomer then composite

Enrollment: 54 patients

Sex: Male

Ages: 20 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age: 20-50 years
• Medically free
• The patient should have the upper first premolar that needs endodontic treatment with apical periodontitis
• Necrotic teeth
• Participants were willing to commit to the entire period of the trial and agreed to sign the written consent after a full explanation of the study.

Exclusion criteria

• Symptomatic irreversible pulpitis
• If the premolar is non restorable
• If the premolar will need a post and core
• Vertical root fracture
• Open apex
• Presence of any systemic disease or allergic reactions.
• Vulnerable group; prisoners, pregnant females, mentally ill, etc…

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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54 participants in 3 patient groups

Control group

No Intervention group

Description:

conventional endodontic treatment, the canals were filled by conventional gutta percha with proper coronal seal

Regeneration group

Active Comparator group

Description:

Cell homing via bleeding induction was done, MTA was applied into the canals at a depth of 3mm, and the access was sealed by light-cured glass ionomer, then composite restorations were placed

Treatment:

Other: cell homing

Cleaning and shaping only group

Experimental group

Description:

Aseptic techniques were used while using the irrigation activation technique to enhance the irrigation effects, after then MTA was applied into the canals at a depth of 3mm, and the access was sealed by light-cured glass ionomer then composite restorations were placed to ensure proper coronal seal

Treatment:

Procedure: Cleaning and shaping only