Outcomes of Liver Transplantation in Low Weight Children After Reducing the Lateral Segment of a Living Donor, Adapting the Shape and Size of the Graft to the Needs of the Recipient

Hospital Italiano de Buenos Aires

Status: Completed

Conditions: Liver Transplantation; Low-weight Children; Hyper-reduced Liver Grafts

Treatments: Procedure: Liver transplantation with hyper-reduced grafts

Study type: Observational

Funder types: Other

Identifiers

NCT03594864

321654

Details and patient eligibility

About

The shortage of organs has always been a problem in pediatric liver transplants due to the lack of donors with an adequate size. Different techniques of hepatic reduction have been described that allow to use larger organs in the pediatric population. However, in these techniques the maximum reduction achieved by segments 2 and 3 is excessive for low-weight children. Since 1997 the liver transplantation group at Hospital Italiano de Buenos Aires has developed and practiced a technique called hepatic hyper-reduction, which consists in reducing the lateral segment of a living donor, adapting the shape and size of the graft to the needs of the recipient. The investigators have performed approximately 50 pediatric liver transplants with live donors in low weight children in whom the hyper-reduction technique has been applied. The aim of the present study is to describe postoperative morbidity and mortality and analyze overall and graft survival.

Enrollment: 58 patients

Sex: All

Ages: 5 months to 17 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• < or = 17 years old.
• Having undergone live donor liver transplantation.
• Having received hyper-reduced liver grafts
• At the Liver Transplantation Unit of the Hospital Italiano de Buenos Aires
• Between June 1997 and April 2018

Exclusion criteria

• > 17 years old.
• Cadaveric liver transplant
• Whole liver grafts.

Trial design

58 participants in 1 patient group

Hyper-reduced liver recipients.

Description:

Low-weight children who underwent live donor liver transplantation with ultrasound-guided in situ left lateral segment graft hyper-reduction.

Treatment:

Procedure: Liver transplantation with hyper-reduced grafts