Outcomes of Periodontal Regenerative Treatment

Queen Mary University of London

Status: Invitation-only

Conditions: Periodontitis; Periodontal Regeneration; Intrabony Periodontal Defect

Study type: Observational

Funder types: Other

Identifiers

NCT04971174

280800

Details and patient eligibility

About

The aim of this recall study is to evaluate outcomes of surgical regenerative treatment of periodontal defects in a cohort of patient previously treated for gum disease at the Royal London Hospital as part of their periodontal care.

Full description

This study will be divided in two parts:

Part 1: a retrospective analysis of short-term outcomes of periodontal regenerative procedures undertaken at the Barts Royal London Dental Hospital (RLDH); Part 2: a single recall visit study in which patients identified through part 1 and willing to consent for the study will be reassessed for medium-term outcomes of the regenerative procedures previously undertaken.

For part 1 historic data will be collected from available dental records at RLDH and divided in:

• Timepoint 0: the latest available full mouth periodontal assessment before surgery and x-ray of site/s needing surgical intervention
• Timepoint 1: the latest available full mouth periodontal assessment after surgery and x-ray of same site/s at Timepoint 0

For part 2 data will be collected from patients identified through part 1 and willing to give consent for a single study recall visit:

•Timepoint 2: single study outcome recall visit (full mouth periodontal assessment and x-ray of same site/s at Timepoint 0).

Due to the nature of the study, the time elapsed between Timepoint 0 and Timepoint 2 can vary between 1 and 4 years.

Enrollment: 200 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Inclusion criteria for part 1 of the study:

• Patient age 18 and older
• Patients that received periodontal regenerative surgical treatment at Barts RLDH from January 2017 to January 2019 with and without the use of any biomaterials, bone graft/substitute and membrane or combinations of those.
• Available full periodontal examination records after non surgical therapy to serve as a baseline for the study and not beyond 12 months before surgery
• Available radiographic examination of the tooth treated with surgical regenerative procedure at initial examination or after non surgical therapy to serve as a baseline for the study.

Additional inclusion criteria for part 2:

-Patient able and willing to give informed consent

Exclusion criteria

Exclusion criteria for part 1:

• All the patients that do not match the inclusion criteria will be excluded from part 1.
• Patients that received regenerative surgical treatment for the management of gingival recession.

Exclusion criteria for part 2:

• Unable or unwilling to give consent
• Pregnant women