Outcomes of PRF on Septoplasty in Patient With Nasal Septal Deviation

Kafrelsheikh University

Status: Not yet enrolling

Conditions: Nasal Septum; Deviation; Nasal Septal Srur

Treatments: Other: Effect of Platelet Rich Fibrin on Septoplasty

Study type: Interventional

Funder types: Other

Identifiers

NCT06996106

PRF in septoplasty

Details and patient eligibility

About

The aim of this study is to assess the effectiveness of Platelet-Rich Fibrin (PRF) in improving postoperative healing, reducing complications, and enhancing functional outcomes in patients undergoing septoplasty

Full description

Septoplasty is a routine surgical intervention to correct nasal septal deviation, a major cause of nasal obstruction and chronic sinusitis. Despite advancements, postoperative complications-such as mucosal injury, synechiae, septal perforation, and hematoma-continue to impact outcomes and patient satisfaction.

Platelet-rich fibrin (PRF), first described by Choukroun et al., represents an autologous biomaterial rich in growth factors like PDGF, TGF-β, VEGF, and IGF-1, known to accelerate wound healing and tissue regeneration. Unlike platelet-rich plasma (PRP), PRF is easier to prepare, does not require anticoagulants, and forms a fibrin matrix conducive to sustained release of cytokines.

Several studies across disciplines-oral surgery, dermatology, orthopedics-support the regenerative potential of PRF. In nasal surgery, the delicate mucosal environment could benefit significantly from enhanced healing facilitated by PRF.

Enrollment: 100 estimated patients

Sex: All

Ages: Under 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Adults aged 18-65 years undergoing septoplasty. Presence of cartilage deviated nasal septum requiring repair. No contraindications to PRF therapy.

Exclusion criteria

• History of coagulopathy or anticoagulant therapy. Active infection or systemic disease. Known hypersensitivity to PRF components. Previous nasal surgery Autoimmune or systemic inflammatory disease

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Parallel Assignment

Masking: Single Blind

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100 participants in 2 patient groups

platelet rich fibrin

Active Comparator group

Description:

usage of platelet rich fibrin in this arm underging setoplasty

Treatment:

Other: Effect of Platelet Rich Fibrin on Septoplasty

control group

Active Comparator group

Description:

traditional septoplasty

Treatment:

Other: Effect of Platelet Rich Fibrin on Septoplasty