Outcomes of RV Dysfunction in Acute Exacerbation of Chronic Respiratory Diseases (DVD)

Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le Sommeil

Status: Unknown

Conditions: Neuromuscular Diseases; Acute Exacerbation of COPD; Acute Exacerbation of Asthma; Acute Respiratory Failure; Acute Exacerbation of Bronchiectasis; Obesity Hypoventilation Syndrome; Interstitial Lung Disease

Study type: Observational

Funder types: Other

Identifiers

NCT04098094

2018-A03192-53

Details and patient eligibility

About

Observational study in patients with chronic respiratory diseases (chronic obstructive pulmonary diseases, bronchiectasis, interstitial lung diseases, neuromuscular diseases, obesity-hypoventilation syndrome...) admitted in intensive care unit for acute respiratory failure. The main objective is to determine the prevalence of right ventricular (RV) dysfunction in this population and to analyze the impact of such a complication on outcomes (survival at day-28, duration of non-invasive or mechanical ventilation, duration of hospital stay). RV function will be assessed by echocardiography at admission, after 3 days and at discharge. Plasma NT-proBNP and troponin levels will be collected.

Full description

Observational study in patients with chronic respiratory diseases (chronic obstructive pulmonary diseases, bronchiectasis, interstitial lung diseases, neuromuscular diseases, obesity-hypoventilation syndrome...) admitted in intensive care unit for acute respiratory failure.

Inclusion Criteria:

• Chronic respiratory disease (COPD, ILD, OHS...)
• Admission in ICU for acute respiratory failure
• Patient's non-opposition

Exclusion Criteria:

• Patients < 18 year-old
• Protected patients
• Pregnant women The main objective is to determine the prevalence of right ventricular (RV) dysfunction in this population and to analyze the impact of such a complication on outcomes (survival at day-28, duration of non-invasive or mechanical ventilation, duration of hospital stay). RV function will be assessed by echocardiography at admission, after 3 days and at discharge. Plasma NT-proBNP and troponin levels will be collected.

Enrollment: 40 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Chronic respiratory disease (COPD, ILD, OHS...)
• Admission in ICU for acute respiratory failure
• Patient's non-opposition

Exclusion criteria

• Patients < 18 year-old
• Protected patients
• Pregnant women