Outpatient Recovery From Acute Kidney Injury Requiring Dialysis (ORKID)

University of California San Francisco (UCSF)

Status and phase: Terminated; Phase 4

Conditions: Acute Kidney Injury; Dialysis Hypotension

Treatments: Drug: Furosemide; Other: ORKID Bundled Intervention

Study type: Interventional

Funder types: Other

Identifiers

NCT05158153

21-33602

Details and patient eligibility

About

There are currently no therapies to improve the chances of recovering enough kidney function to come off of dialysis after severe acute kidney injury. It is not known if current routine outpatient dialysis treatments are optimized to maximize the chances of recovery. The purpose of this pilot study is to see if we can feasibly and safely provide several changes to the way that dialysis is provided in outpatient dialysis centers which may improve the chances of recovery.

Enrollment: 1 patient

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• AKI-D (acute kidney injury requiring dialysis), attributed at least in part to acute tubular necrosis by clinical nephrology team
• Age ≥ 18 years
• Pre-hospitalization eGFR ≥ 15 mL/min/1.73m2
• Being discharged to a participating outpatient dialysis unit (within 30 miles of UCSF)

Exclusion criteria

• Known loop diuretic allergy/intolerance
• Dialysis duration > 3 months
• Pregnant
• Prisoner
• Unable to consent
• Clinical team declines to allow approach for study

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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1 participants in 1 patient group

ORKID Bundled Intervention

Experimental group

Treatment:

Drug: Furosemide

Other: ORKID Bundled Intervention