Outpatient Versus Inpatient Detoxification Program for Alcohol Dependent Patients Seeking Abstinence: The IN/OUT Study

Assistance Publique - Hôpitaux de Paris

Status: Completed

Conditions: Alcoholism; Alcohol Dependence

Treatments: Procedure: Outpatient detoxification program

Study type: Interventional

Funder types: Other

Identifiers

NCT00226720

AOM98176

P000807

Details and patient eligibility

About

Detoxification, in an inpatient or outpatient program, is the primary and essential step for managing alcohol dependence. The superiority of one or other method of detoxification has never been proved in several previous randomized clinical trials (RCT). The aim of this multicenter RCT was to compare efficiency, on the abstinence rate as the primary outcome, at 1 and 3 months follow-up of two alcohol detoxification programs (a 5/7-days inpatient detox vs. an ambulatory detox).

Full description

Among patients consulting in 4 alcohol treatment centers in France seeking treatment for withdrawal, we included those who met criteria for current alcohol-dependence (DSM IV) and having drinking during the past three days before randomization. Exclusion criteria were: patients' refusal of one or other method, contraindication for outpatient detoxification method (history of DELIRIUM TREMENS or withdrawal seizures), homelessness, Major Depressive Episode assessed by MADRS > 25, current Substance Abuse Disorder (except nicotine), indication for hospitalization (severe somatic disorder), judicial injunction, family crisis, patients seeking antabuse treatment.

Enrollment: 500 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Alcohol dependence according to DSM IV
• Detoxification program requested by patients

Exclusion criteria

• Refusal of the patient for the hospitalization or ambulant weaning alcoholic
• contraindication in ambulant weaning
• The state of the patient requires a hospitalization
• Ask of the patient for a treatment by the ESPERAL

Trial design

500 participants in 2 patient groups

1

Experimental group

Description:

at the hospital

Treatment:

Procedure: Outpatient detoxification program

2

Active Comparator group

Description:

out of the hospital

Treatment:

Procedure: Outpatient detoxification program