Ovarian Hyperstimulation Syndrome (OHSS) Prevention With Agonist

University Hospital Schleswig-Holstein (UKSH)

Status: Completed

Conditions: Ovarian Hyperstimulation Syndrome

Study type: Observational

Funder types: Other

Identifiers

NCT00835523

OHSS 2009

Details and patient eligibility

About

The aim of the study is to explore the concept of GnRH-agonist triggering in combination with elective cryopreservation of all 2PN oocytes at larger scale in a pragmatic clinical setting. The question asked is: "Does GnRH-agonist triggering and cryopreservation work", in terms of efficacy and safety, when applied to a larger cohort of patients, and by a number of different centres with different clinical routines.

Enrollment: 51 patients

Sex: All

Ages: 18 to 39 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Indication for IVF with ICSI
• Age < 40 years
• < 4 failed previous IVF attempts with embryo transfer
• ovarian stimulation with GnRH-antagonist and gonadotrophins
• >20 follicles >11 mm in mean diameter or E2 >4500 pg/ml on the day , on which it was planned to administer hCG
• willing to participate and able to consent
• patient has not previously received GnRH-agonist as a trigger of final oocyte maturation

Exclusion criteria

• None

Trial design

51 participants in 1 patient group

OHSS risk