Ovarian PRP Injections for Improved Embryo Quality Using Embryo Quality Score

Generation Next Fertility

Status: Enrolling

Conditions: Poor Ovarian Reserve; Infertility; in Vitro Fertilization; Embryo Growth Disorder

Treatments: Procedure: Ovarian Platelet-rich plasma (PRP) injections

Study type: Interventional

Funder types: Other

Identifiers

NCT07020546

IORG0010499-012025

Details and patient eligibility

About

Patients will have ovarian PRP treatments and embryo development will be observed using time-lapse imaging and AI software.

Full description

. oPRP Treatment & Second IVF Cycle (Study Cycle)

• Following the first IVF cycle, patients will undergo their first oPRP injection:

  • Timing: 1-2 weeks after the onset of the next menstrual cycle.
  • Procedure: Under IV sedation, a patient's autologous PRP will be prepared and injected directly into both ovaries under transvaginal ultrasound guidance.

• Second IVF Cycle (oPRP Study Cycle)

  • The same ovarian stimulation protocol will be used for consistency.
  • A second oPRP injection will be performed on stimulation days 2-5 to enhance folliculogenesis.
  • Ovulation will be triggered at the same follicular size thresholds, and oocyte retrieval will follow identical protocols.
  • Fertilization methodology will be identical to the first cycle unless no fertilization is identified in the first cycle.
  • Embryo Development Analysis: Up to 15 embryos will be cultured in the AI incubator, where time-lapse imaging will track their morphokinetics, and AI-based analysis will assess embryo viability and implantation potential.

Enrollment: 180 estimated patients

Sex: Female

Ages: 18 to 47 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• No none contraindications to IVF or PRP treatment
• Adequate ovarian reserves and AMH level
• Willingness to undergo two IVF cycles and oPRP treatment

Exclusion criteria

• Anovulation due to menopause or perimenopause
• Any health conditions that are contraindicated for IVF or oPRP treatment

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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180 participants in 1 patient group

Embryo Development Before and After Ovarian PRP Using Time-Lapse AI Embryo Quality Score

Experimental group

Description:

Patients will undergo two IVF cycles. The first cycle will be before ovarian PRP treatment and the second will be after. The embryo development measured by data gathered in time-lapse imaging and AI software will be used to determine differences between the groups within the same patient

Treatment:

Procedure: Ovarian Platelet-rich plasma (PRP) injections