Ovarian Reserve and Ankylosing Spondylitis

Kanuni Sultan Suleyman Training and Research Hospital

Status: Completed

Conditions: Ankylosing Spondylitis; Anti-Mullerian Hormone Deficiency; Ovarian Diseases

Treatments: Other: ovarian reserve for Ankylosing spondylitis and control groups

Study type: Observational

Funder types: Other

Identifiers

NCT04209881

2019/456.14.10.2019

Details and patient eligibility

About

The aim of this study was to determine the status of ovarian reserve in patients with ankylosing spondylitis (AS) using anti-mullerian hormone (AMH) level and antral follicle count (AFC). Women with AS and women controls diagnosed according to the classification criteria proposed by the American-European Consensus Group will be included in the study. Ovarian reserve will be evaluated in terms of clinical findings, AFC and serum AMH and reproductive hormone levels.

Researchers predict that the ovarian reserve may be reduced in patients with AS due to the autoimmune process and the pathophysiology of the disease. Serum AMH and ovarian AFC may be useful for assessing ovarian reserve. It is aimed to determine the course of ovarian reserve abnormalities and the best possible biomarkers of reduced ovarian reserve in patients with AS.

Enrollment: 50 patients

Sex: Female

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• regular menstruation with intervals of 21-35 days;
• cycle length variations <4 days;
• both ovaries still present

Exclusion criteria

• history of liver failure;
• diagnosed malignancy;
• cigarette smoking;
• chronic renal failure;
• known infertility;
• presence of gynecological abnormalities such as abnormal uterine bleeding or menorrhagia;
• history of ovarian surgery;
• history of hormone preparation (including corticosteroids) use or use of herbal products within 3 months;
• diagnosis of polycystic ovary syndrome.

Trial design

50 participants in 2 patient groups

Patients with Ankylosing spondylitis

Description:

Women Who Are Diagnosed With Ankylosing Spondylitis Will Form The Study Group. Clinical And Laboratory Parameters Will Be Evaluated For Ovarian Capacity Of These Women.In order to evaluate the ovarian reserve of the patients, the parameters we routinely look at will be evaluated as follows. the results of these tests will be observed. Amh Will Be Looked For (Pmol / L). Antral Folukul Census In The Overin Folukular Stage Will Be Valued As Number. Fsh (Iu / L) And Estradiol (Pmol / L) Values Will Also Be Recorded.

Treatment:

Other: ovarian reserve for Ankylosing spondylitis and control groups

Healthy women as controls

Description:

Regular menstruation with intervals of 21-35 days; cycle length variations \<4 days; and both ovaries still present healthy women will create the control group.In order to evaluate the ovarian reserve of the patients, the parameters we routinely look at will be evaluated as follows. the results of these tests will be observed. Amh will be looked for. (pmol / l). Antral folukul census in the overin folukular stage will be valued as number. Fsh (iu / l) and Estradiol (pmol / l) values will also be recorded.

Treatment:

Other: ovarian reserve for Ankylosing spondylitis and control groups