Ovarian Reserve in Crohn's Disease

Kanuni Sultan Suleyman Training and Research Hospital

Status: Completed

Conditions: Ovary Disease; Crohn Disease; Anti-Mullerian Hormone Deficiency

Treatments: Other: AMH levels in young women with crohn's disease will be considered.

Study type: Observational

Funder types: Other

Identifiers

NCT03897400

2019.03.40

Details and patient eligibility

About

Crohn's disease reduces fertility by inducing inflammation both directly and in the fallopian tubes and ovaries and indirectly through surgical interventions and tubal adhesions associated with disease treatment. Anti-mullerian hormone (AMH) is a reliable indicator of ovarian reserve in women. The aim of this study was to compare serum AMH levels in women with Crohn's disease and healthy controls. In this study, the investigators aimed to investigate AMH and ovarian capacity in the study group with crohn's disease and in the control group without disease.

Enrollment: 100 patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• crohn's disease;
• reproductive age women

Exclusion criteria

• Over 40 years old,
• a previous ovarian resection;
• renal failure (serum creatinine levels N1.2 mg / dL);suspicion of malignancy;
• the presence of hereditary or acquired hematological disease;
• pregnancy;
• current lactation;
• the presence of a serious comorbid chronic disease;
• cirrhosis originating from chronic liver disease;
• abnormal thyroid function tests;
• a known serious psychological problem;
• presence of alcoholism and male sex.

Trial design

100 participants in 2 patient groups

study group

Description:

women in reproductive age with crohn's disease

Treatment:

Other: AMH levels in young women with crohn's disease will be considered.

control group

Description:

women in reproductive age without crohn's disease,

Treatment:

Other: AMH levels in young women with crohn's disease will be considered.