Ovarian Reserve in Diabetes Mellitus

Kanuni Sultan Suleyman Training and Research Hospital

Status: Completed

Conditions: Type1 Diabetes Mellitus

Treatments: Other: hormone panel and ultrasonography

Study type: Observational

Funder types: Other

Identifiers

NCT03859856

2018.10.23

Details and patient eligibility

About

Type 1 diabetes mellitus is a common autoimmune disease. It affects women of all ages including reproductive years. Hyperglycemic condition in diabetes can cause organ damage. This study aims to measure serum hormones including FSH, LH, E2, AMH, ovarian volume and antral follicle count (indicators of ovarian reserve) in women with and without type 1 diabetes mellitus.

Full description

Type 1 diabetes mellitus is a common autoimmune disease. It affects women of all ages including reproductive years. It is showed that hyperglycemic state in diabetes results in organ damage like kidneys and eyes. Ovarian reserve is important for the reproductive period. The measurements of serum hormones including follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2) and anti-mullerian hormone (AMH) will give us an idea about the ovarian reserve. The investigators aim is to measure ovarian reserve parameters in patients diagnosed with type 1 diabetes mellitus and to compare them to healthy controls. Serum FSH, LH, E2 and AMH will be measured on the 3rd day of the cycle. Antral follicle count and ovarian volume measurement will be done with ultrasonography. Ovarian reserve markers will be compared between the groups.

Enrollment: 100 patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Reproductive age group women: 18-40 years
• Women diagnosed with type 1 diabetes (case group)
• Women without type 1 diabetes (control group)

Exclusion criteria

• Women with PCOS (polycystic ovary syndrome)
• history of ovarian surgery
• Body mass index (BMI) over 30

Trial design

100 participants in 2 patient groups

women with Type 1 diabetes mellitus

Description:

Reproductive age women diagnosed with type 1 diabetes mellitus

Treatment:

Other: hormone panel and ultrasonography

women without Type 1 diabetes mellitus

Description:

Reproductive age women diagnosed with type 1 diabetes mellitus to serve as control

Treatment:

Other: hormone panel and ultrasonography