Ovarian Reserve in Intensive Care Patients

Haseki Training and Research Hospital

Status: Not yet enrolling

Conditions: Anti-Mullerian Hormone Deficiency

Treatments: Behavioral: Glaskow coma scala, The Acute Physiology and Chronic Health Evaluation System- APACHE, Injury Severity Score- ISS)

Study type: Observational

Funder types: Other

Identifiers

NCT06999291

OR-2024

Details and patient eligibility

About

Gastrointestinal, pulmonary, nephrological, cardiac, neurologic and psychological effects in critically ill patients followed in the intensive care unit have been shown in the literature. However, the effects on ovarian reserve in these patients have not been sufficiently investigated and studies investigating this issue are limited in the literature. The synthesis, release frequency and amplitude of reproductive hormones change under stress. In addition, changes in ovarian homeostasis affect ovarian reserve. The aim of this study was to evaluate ovarian reserve in critically ill patients followed up in the intensive care unit.

Enrollment: 75 estimated patients

Sex: Female

Ages: 18 to 35 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 18-35 years of age
• Female patients followed in the intensive care unit for more than 24 hours for internal or surgical reasons,
• Women whose ovarian reserve is being evaluated,

Exclusion criteria

• Previous ovarian surgery, endometriosis, endometrioma,
• History of chemotherapy, radiotherapy,
• Ovarian cyst, malignancy and other ovarian pathologies,
• Women with single ovary,
• Women receiving hormone therapy,
• Polycystic ovary syndrome,
• Surgical intervention within the last 6 months,
• History of drug, alcohol, substance use,
• Women in pregnancy, puerperium, lactation,
• History of vaccination within the last 6 months

Trial design

75 participants in 3 patient groups

internal intensive care

Description:

Patients hospitalized in intensive care for internal reasons

Treatment:

Behavioral: Glaskow coma scala, The Acute Physiology and Chronic Health Evaluation System- APACHE, Injury Severity Score- ISS)

surgical intensive care

Description:

Patients hospitalized in intensive care for surgical reasons

Treatment:

Behavioral: Glaskow coma scala, The Acute Physiology and Chronic Health Evaluation System- APACHE, Injury Severity Score- ISS)

Outpatient clinic patients

Description:

Healthy female patients admitted to gynecology outpatient clinic

Treatment:

Behavioral: Glaskow coma scala, The Acute Physiology and Chronic Health Evaluation System- APACHE, Injury Severity Score- ISS)