Ovarian Reserve in Patients With Psoriasis

Kanuni Sultan Suleyman Training and Research Hospital

Status: Completed

Conditions: Psoriasis; Anti Mullerian Hormone; Ovarian Reserve

Treatments: Other: Hormone panel

Study type: Observational

Funder types: Other

Identifiers

NCT03492632

2017/325

Details and patient eligibility

About

Psoriasis is a common autoimmune disease. It affects women of all ages including reproductive years. Autoimmune diseases including psoriasis are linked to premature ovarian reserve. This study aims to measure serum hormones including FSH,LH,E2,PRL and AMH (indicators of ovarian reserve) in women with and without psoriasis.

Full description

Psoriasis is a common autoimmune disease. It affects women of all ages including reproductive years. Almost 75% of patients are diagnosed before the age of 40. There is also increased evidence on autoimmune disease and their link to premature ovarian failure.Ovarian reserve is important for the reproductive period. The measurements of serum hormones including follicle stimulating hormone (FSH),luteinizing hormone (LH),prolactin (PRL), estradiol (E2) and anti-mullerian hormone (AMH) will give us an idea about the ovarian reserve. The investigators aim is to measure ovarian reserve parameters in patients newly diagnosed with psoriasis and to compare them to healthy controls. Serum FSH,LH,E2,PRL and AMH will be measured on the 3rd day of the cycle.The serum hormone levels will be compared between women with psoriasis and women without psoriasis

Enrollment: 72 patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Reproductive age group women: 18-40 years
• Women diagnosed with psoriasis (case group)
• Women without psoriasis (control group)

Exclusion criteria

• Women with PCOS (polycystic ovary syndrome)
• history of ovarian surgery
• Body mass index (BMI) over 30
• Women with other autoimmune diseases including Hashitomo thyroiditis
• Women with family history of premature ovarian insufficiency (POI)
• Women with infertility
• Psoriasis using systemic drugs including steroids and immunosuppressive therapy.

Trial design

72 participants in 2 patient groups

Women with Psoriasis

Description:

Reproductive age women newly diagnosed with psoriasis

Treatment:

Other: Hormone panel

Women without Psoriasis

Description:

Reproductive age women without psoriasis to serve as control

Treatment:

Other: Hormone panel