Ovarian Tissue Cryopreservation and Subsequent Auto-Transplantation for Female Cancer Patients

The Chinese University of Hong Kong

Status

Enrolling

Conditions

Neoplasms

Treatments

Procedure: Ovarian tissue freezing and subsequent auto-transplantation after thawing

Study type

Interventional

Funder types

Other

Identifiers

NCT05830929

2023.096-T

Details and patient eligibility

About

Ovarian Tissue Cryopreservation will be provided to cancer patients to allow them to have their fertility preserved.

Full description

This project hopes to provide Ovarian Tissue Cryopreservation to patients who do not have adequate time for ovarian stimulation in oocyte or embryo freezing and in prepubertal girls where oocyte freezing is not possible. All the patients will have fertility preservation consultations with a fertility specialist in our unit to go through the details of ovarian Tissue Cryopreservation service and risks related to ovarian tissue cryopreservation procedures. After undergoing ovarian tissue collection via surgery, the collected ovarian tissue will be cryopreserved either by slow freezing or vitrification in our unit.

Enrollment

100 estimated patients

Sex

Female

Ages

1 month to 35 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients aged from 0-35 years old and diagnosed with cancer e.g., leukaemia, myeloproliferative or myelodysplastic diseases, lymphoma, bone tumours, neurological neoplasms and sarcoma, Paediatric bone marrow transplant patients
Patients with any illness or who will undergo any type of treatment that may cause irreversible damage to their fertility, such as extensive abdominal surgery, high toxicity medication and treatments;
Patients suffering from hormone-sensitive malignancies who will undergo medical treatment, such as radiotherapy and chemotherapy that is liable to damage their ovaries and deter them from conception in the future.

Exclusion criteria

Patients with no anticipated oncologic therapies
Patients who are pregnant
Children with one ovary
Children deemed high risk for perioperative complications
Patients unable to provide consent/assent (i.e. significant psychiatric problems/cognitive delay)