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Ovarian Tissue Cryopreservation in Females Undergoing Procedures That Will Potentially Lead To Loss of Ovarian Function

Medical College of Wisconsin logo

Medical College of Wisconsin

Status

Completed

Conditions

Auto Immune Disease
Effects of Chemotherapy
Cancer
Unspecified Complication of Bone Marrow Transplant

Treatments

Procedure: Retrieval and Cryopreservation

Study type

Interventional

Funder types

Other

Identifiers

Details and patient eligibility

About

The purpose of this study is to retrieve and cryopreserve ovarian tissue from females undergoing a treatment that may lead to irreversible loss of ovarian function.

Full description

The aim of this preliminary study is to retrieve and properly cryopreserve ovarian tissue for autotransplantation in any premenopausal female whose ovarian function is threatened in a physiological, pathological or iatrogenic manner in an effort to observe the return of ovarian endocrine function and development of egg(s) appropriate for use in in vitro fertilization.

Enrollment

15 patients

Sex

Female

Ages

3+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Patient must be female.
  • Patient must have a disease process where the disease or its treatment adversely affects ovarian function.
  • Patient must be recommended for this study by their oncologist or specialist.
  • Patient (or legally authorized representative) must sign an informed consent.

Exclusion criteria

  • Patients cannot be male.
  • Patients must not be HIV positive.
  • Patient cannot have a poor diagnosis such that she is not expected to survive to adulthood.
  • Patient cannot have any medical condition that would contraindicate surgery.
  • Patient cannot have any medical condition that would contraindicate general anesthesia.
  • Patient cannot have any medical condition that would contraindicate pregnancy.

Trial design

Primary purpose

Prevention

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

15 participants in 1 patient group

Retrieval and Cryopreservation
Experimental group
Description:
Females undergoing therapeutic procedures that will potentially lead to the irreversible loss of ovarian function will have their ovarian tissue retrieved and cryopreserved. Ideally, after treatment, the cryopreserved ovarian tissue can be thawed and auto-transplanted and ovarian function resumed.
Treatment:
Procedure: Retrieval and Cryopreservation

Trial contacts and locations

2

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Data sourced from clinicaltrials.gov

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