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Ovarian Tissue Transplantation

Abramson Cancer Center at Penn Medicine logo

Abramson Cancer Center at Penn Medicine

Status

Enrolling

Conditions

Infertile Females or Females With Ovarian Insufficiency

Treatments

Procedure: Transplantation of previously cryopreserved ovarian tissu

Study type

Interventional

Funder types

Other

Identifiers

NCT01870752
UPCC 02813

Details and patient eligibility

About

Chemotherapy and radiation therapy for the treatment of cancer can compromise fertility. Ovarian tissue cryopreservation is an experimental strategy offered at The University of Pennsylvania to preserve future fertility (protocol 806062). The primary objective of this study is to determine the efficacy and safety of autologous transplantation of previously cryopreserved ovarian cortical tissue in patients who experience infertility or ovarian insufficiency after cancer treatments.

Enrollment

10 estimated patients

Sex

Female

Ages

18 to 45 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Female patient between the ages of 18 and 45 years
  • Previously cryopreserved and stored cortical ovarian tissue available for autologous transplantation
  • Ovarian insufficiency defined as an elevated FSH over 10
  • Inability to conceive after 6 months of unprotected intercourse with male
  • Reasonably good health
  • Candidate for pregnancy
  • Written clearance for the procedure from the patients oncologist

Exclusion criteria

  • Patients considered to be high risk for surgical complications will be excluded from the research protocol
  • Women who are known to be positive for the BRCA mutation
  • Women with a history of leukemia, ovarian cancer or a cancer that likely involved the ovaries at the time of ovarian tissue collection
  • Women with psychological, psychiatric, or other conditions which prevent giving fully informed consent
  • Current pregnancy

Trial design

Primary purpose

Treatment

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

10 participants in 1 patient group

Transplantation of previously cryopreserved ovarian tissue
Other group
Description:
Surgical transplantation of previously collected cryopreserved ovarian cortical tissue.
Treatment:
Procedure: Transplantation of previously cryopreserved ovarian tissu

Trial contacts and locations

1

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Central trial contact

Clarisa Gracia, MD

Data sourced from clinicaltrials.gov

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