OVEMP in Myasthenia

University of Zurich (UZH)

Status: Completed

Conditions: Myasthenia Gravis, Ocular

Treatments: Diagnostic Test: Ocular vestibular evoced myogenic potentials

Study type: Interventional

Funder types: Other

Identifiers

NCT03049956

2016-01109

Details and patient eligibility

About

Myasthenia gravis is an autoimmune disorder of neuromuscular transmission, characterized by fluctuating muscle weakness and fatigability. In isolated ocular myasthenia, when only the extraocular muscles are involved, most common ancillary tests, such as acetylcholine receptor autoantibodies and repetitive nerve stimulation, are often negative.

A simple, quick and non-invasive test for ocular myasthenia based on ocular vestibular evoked myogenic potentials (oVEMP) was recently developed.

The main goal of the study is to validate repetitive oVEMP stimulation in a blinded diagnostic accuracy study in order to facilitate early and accurate diagnosis of ocular myasthenia.

Enrollment: 96 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Informed Consent as documented by signature
• Patients with diplopia and/or ptosis suspicious for myasthenia gravis.

Exclusion criteria

• Vestibular disorders
• Significant systemic myasthenia symptoms (respiration or swallowing difficulties) unable to undergo oVEMP testing.
• Patients with significant cardiac or respiratory disease will be excluded from the Tensilon test as part of the reference standard.
• Women who are pregnant or breast feeding.

Trial design

96 participants in 1 patient group

Patients with clinical suspicion of ocular myasthenia gravis

Experimental group

Treatment:

Diagnostic Test: Ocular vestibular evoced myogenic potentials