Over-night Effect of Dietary Fiber on Glucose Metabolism and Satiety

Lund University

Status and phase: Completed; Early Phase 1

Conditions: Obesity; Metabolic Syndrome

Treatments: Other: Low levels of indigestible carbohydrates; Other: High levels of indigestible carbohydrates

Study type: Interventional

Funder types: Other

Identifiers

NCT02347293

Dnr2013/241b

Details and patient eligibility

About

The experimental model is a semi-acute, over-night, study where the purpose is to evaluate food factors related to colonially derived regulation and satiety in healthy subjects.

Enrollment: 21 patients

Sex: All

Ages: 20 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Normal fasting blood glucose
• BMI 19-25 kg/m2

Exclusion criteria

• Gastrointestinal diseases
• Food allergies e.g. lactose-, gluten intolerance
• Metabolic disorder e.g. diabetes
• Tobacco/snuff users
• No antibiotic or probiotic intake 2 weeks prior and during study.
• Vegetarians

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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21 participants in 2 patient groups

+ ind. CHO

Experimental group

Description:

Test meals: intake of high levels of indigestible carbohydrates the evening prior to measurements of variables

Treatment:

Other: High levels of indigestible carbohydrates

- ind. CHO

Experimental group

Description:

Reference meal: scarce intake of indigestible carbohydrates the evening prior to measurements of variables

Treatment:

Other: Low levels of indigestible carbohydrates