Overeating Different Fats and Influence on Muscle Mass and Body Fat Accumulation (LIPOGAIN-2)

Uppsala University

Status: Completed

Conditions: Ectopic Fat; Muscle Mass; Overfeeding; Obesity; Body Composition

Treatments: Dietary Supplement: SFA-group; Dietary Supplement: PUFA-group

Study type: Interventional

Funder types: Other

Identifiers

NCT02211612

LIPOGAIN-2

Details and patient eligibility

About

To investigate metabolic and molecular response to fatty acid-specific overfeeding in overweight subjects, in relation to changes in ectopic fat, lean tissue mass and insulin sensitivity

Enrollment: 60 patients

Sex: All

Ages: 30 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Body mass index 25-32

Exclusion criteria

• Type 2 diabetes
• Type 1 diabetes
• Kidney disease
• Liver disease
• Abnormal clinical chemistry at screening
• Intense physical exercise > 2 hours per week
• Use of statins or drugs affecting energy metabolism
• Use of extreme diets

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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60 participants in 2 patient groups

Saturated fatty acids (SFA)-group

Experimental group

Description:

Weight gain created by addition of muffins baked on saturated fat

Treatment:

Dietary Supplement: SFA-group

Polyunsaturated fatty acids (PUFA)-group

Experimental group

Description:

Weight gain created by addition of muffins baked on polyunsaturated fat

Treatment:

Dietary Supplement: PUFA-group