Ovulation Trigger With hCG Compared to GnRH Agonist in Patients With Repeated IVF Failures

Rambam Health Care Campus

Status and phase: Completed; Phase 4

Conditions: Infertility

Treatments: Drug: hCG trigger; Drug: GnRH agonist trigger

Study type: Interventional

Funder types: Other

Identifiers

NCT02048891

RMB-0427-13

Details and patient eligibility

About

Ovulation trigger is needed in in vitro fertilization (IVF) to get mature eggs. Routinely, human chorionic gonadotropin (hCG) is used for that purpose given its similarity to the natural hormone that does this job in a natural cycle (luteinizing hormone, LH). In a natural cycle another hormone takes part in the process (follicle stimulating hormone, FSH). To induce a natural-like ovulation surge that includes LH and FSH , gonadotropin releasing hormone (GnRH) agonist can be given.

The purpose of this study is to find out which approach may work better in IVF patients who experienced 4 IVF failures.

Enrollment: 3 patients

Sex: Female

Ages: 35 to 44 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• IVF patients with at least 4 consecutive failures.
• On trigger day, no more than 10 follicles of 12 mm and up

Exclusion criteria

• History of moderate or severe OHSS.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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3 participants in 2 patient groups

hCG trigger

Active Comparator group

Description:

Ovulation trigger with Ovitrelle 250 microgram, luteal support with vaginal progesterone: gel Crinone 8% daily.

Treatment:

Drug: hCG trigger

GnRH agonist trigger

Experimental group

Description:

ovulation trigger with Decapeptyl 0.2 mg, luteal support with 2 injections of 1,500 U hCG.

Treatment:

Drug: GnRH agonist trigger