Oxidation-reduction Homeostasis in Cognitive Impairment Patients After Stroke

H

Hui-Sheng Chen

Status

Completed

Conditions

Post-stroke Cognitive Impairment
Oxidative-reduction Homeostasis

Treatments

Other: No intervention has been conducted

Study type

Observational

Funder types

Other

Identifiers

NCT03519828
k(2017)34

Details and patient eligibility

About

Cognitive impairment after ischemic stroke can affect not only the social adaptation ability, but also affect the comprehensive rehabilitation of patients. The damage of cognitive impairment after ischemic stroke is not lower than the body function defect after stroke. Many studies have shown that oxidative stress is one of the pathophysiological mechanisms of ischemic cerebrovascular disease. Many studies have reported that the oxidative-reduction of cells plays an important role in the life activities of organisms, affecting the health, aging and death of the organism. In the recent years, some scholars have suggested that post-stroke cognitive impairment may be related to oxidative-reduction homeostasis of the body, but the relevant evidence is lacking and needs to be further explored. Therefore, the purpose of this study is to explore the effect of oxidation-reduction homeostasis on cognitive impairment in patients with ischemic stroke, and provide a theoretical basis for the prevention and treatment of cognitive impairment after ischemic stroke.

Enrollment

100 patients

Sex

All

Ages

40 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • 40-80 years old;
  • Ischemic stroke for the first time or previous stroke but with no serious sequelae (mRS is 0 -2 points);
  • Time from onset to treatment ≤48 hours;
  • Conscious awareness, and with no obvious aphasia and visual impairment;
  • Signed informed consent by patient self or legally authorized representatives.

Exclusion criteria

  • Intracranial hemorrhage or suspected subarachnoid hemorrhage;
  • Transient ischemic attack;
  • Patients with severe mental disorders or language disorders;
  • Patients can not cooperate with evaluators, such as mental illness or dementia;
  • Pregnant women or suckers;
  • Researchers consider patients inappropriate to participate in the registry.

Trial design

100 participants in 2 patient groups

Patients with post-stroke cognitive impairment
Treatment:
Other: No intervention has been conducted
Patients without post-stroke cognitive impairment
Treatment:
Other: No intervention has been conducted

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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