Oxidative Stress and Cardiac Arrest

Institut d'Anesthesiologie des Alpes Maritimes

Status: Completed

Conditions: Heart Arrest

Study type: Observational

Funder types: Other

Identifiers

NCT00888966

IAAM 2009-2

Details and patient eligibility

About

Cardiac arrest is a major health problem reaching 375000 cases in Europe each year. Only 5 to 31 % survive after an out of hospital cardiac arrest (OHCA). The main complication after OHCA is the anoxic encephalopathy. Recently mild hypothermia has shown a beneficial effect on survival. But the mechanisms underlying these therapy are not clear.

Cardiac arrest is an example of ischemia reperfusion of the entire body. And it is well demonstrated that reperfusion generates an oxidative stress. But it has never been shown in a clinical setting.

The aim of the study is to evaluate oxidative stress after out of hospital cardiac arrest treated with mild hypothermia.

Enrollment: 40 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Out of hospital cardiac arrest

Exclusion criteria

• refractory shock
• moribund patient
• resuscitation > 60 minutes
• hypothermia < 30 degrees

Trial design

40 participants in 1 patient group

Out of hospital cardiac arrest

Description:

Out of hospital cardiac patients successfully resuscitated and admitted to ICU