Oxidative Stress and Vitamin D Levels in Autism Spectrum Disorders

Mardin Artuklu University

Status

Completed

Conditions

Autism Spectrum Disorders

Study type

Observational

Funder types

Other

Identifiers

NCT06983379

10354421-2019/5

Details and patient eligibility

About

Oxidative Stress and Vitamin D Levels in Autism Spectrum Disorders

Full description

Introduction:

The etiology of Autism Spectrum Disorder (ASD) is thought to be complex. Increasing evidence in the literature shows that oxidative stress plays a role in the development and prognosis of autism. In our study, investigators aimed to investigate whether thiol disulfide balance, which is a new marker of oxidative stress, is different from that in normal children with autism spectrum disorder.

Methods A total of 68 children, 38 with autism spectrum disorder and 30 healthy controls, were included in the study. Dynamic thiol balance, total oxidant status, total antioxidant status, ischemia-modified albumin, paraoxonase 1, and arylesterase activities were measured using colorimetric methods. Routine biochemical parameters were obtained from their files and evaluated.

Enrollment

68 patients

Sex

All

Ages

Under 18 years old

Volunteers

Accepts Healthy Volunteers

Inclusion and exclusion criteria

Control group inclusion criteria:

Healthy children who applied to the pediatric clinic for routine examination

Control group exclusion criteria:

Children who have any chronic medical diseases or psychiatric disorders
Children who have a family history of chronic medical diseases or psychiatric disorders

Autism spectrum disorder group inclusion criteria:

Children with autism spectrum disorder (Diagnosis based on the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision (DSM-5-TR))

Autism spectrum disorder group exclusion criteria: