Oxidative Stress as an Acute Exercise-induced Mechanism of Stem and Progenitor Cell Mobilization (EISMO)

Federal Institute of Technology (ETH) Zurich

Status: Completed

Conditions: Healthy

Treatments: Dietary Supplement: Antioxidative supplementation

Study type: Interventional

Funder types: Other

Identifiers

NCT03747913

EISMO

Details and patient eligibility

About

It is already known from literature that exercise mobilizes stem and progenitor cells into the peripheral blood. However, the exact mechanisms thereof remain to be fully elucidated.

The investigators hypothesize that exercise-induced oxidative stress could be at least one of the responsible mechanisms and therefore want to study the exercise-induced stem and progenitor cell mobilization in a group of healthy young men when they exercise with, compared to when they exercise without antioxidative supplementation.

The primary outcome is numbers of stem and progenitor cells in the peripheral blood after an acute bout of exercise. As a secondary outcome, numbers of apoptotic mature and immature cells in the blood will be analysed.

Enrollment: 18 patients

Sex: Male

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Non-smoking
• Healthy
• Normal Body-Mass-Index (BMI): 18.5-24.9 kg∙m-2
• Active (fulfill World Health Organization-guidelines for recommended levels of physical activity for adults aged 18 - 64 years)
• Willing to adhere to the study rules

Exclusion criteria

• Known or suspected non-compliance, drug or alcohol abuse
• Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders etc. of the participant
• Previous enrolment into the current study
• Enrolment of the investigator, his/her family members, employees and other dependent persons
• Regular intake of medication
• Regular intake of antioxidant supplementations

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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18 participants in 1 patient group

Antioxidative Supplementation

Experimental group

Description:

Each participant conducts two identical cycling tests, first without and a week later with antioxidative supplementation

Treatment:

Dietary Supplement: Antioxidative supplementation