Oxidative Stress In Stargardt Disease, Age Related Macular Degeneration and Diabetic Retinopathy

Johns Hopkins University

Status

Terminated

Conditions

Stargardt Disease

Macular Degeneration (Age Related)

Diabetic Retinopathy

Treatments

Other: Anterior Chamber (AC) Tap

Study type

Observational

Funder types

Other

Identifiers

NCT02875704

OXI-SAD (Other Identifier)

IRB00112564

Details and patient eligibility

About

In this study, markers of oxidative stress will be measured in the aqueous humour of stargardt disease, age related macular degeneration and diabetic retinopathy patients compared to controls.

Full description

People with Stargardt disease, age related macular degeneration (AMD) and diabetic retinopathy (DR) have decrease in central vision from damage to photoreceptors. One of the mechanisms causing damage is high levels of oxygen in the eye. This damage produces specific biomarkers that can be measured in eye fluid (aqueous humor). In this study, these biomarkers will be assessed in people with Stargardt disease, age related macular degeneration and diabetic retinopathy, compared to controls.

Enrollment

77 patients

Sex

All

Ages

18 to 100 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Signed informed consent and authorization of use and disclosure of protected health information
Age at least 18 years
For the study group, patients diagnosed with Stargardt disease, age related macular degeneration and diabetic retinopathy by the investigators, based on clinical phenotype
For the control group, patients with no retinal disease undergoing cataract surgery will be eligible.

Exclusion criteria

• None