Oxidative Stress Markers in COPD

Minia University

Status: Completed

Conditions: Role of Oxidative Stress in COPD

Treatments: Other: oxidative stess markers

Study type: Observational

Funder types: Other

Identifiers

NCT04748887

oxidative stress

Details and patient eligibility

About

Background:Striking feature of Chronic obstructive pulmonary disease (COPD) is its inability to resolve after cigarette smoke exposure has ended, which has contributed to the possibility that the disease could also be driven by other endogenous causes, such as autoimmunity or chronic infection . Many of the pathogenetic pathways involved in COPD and its development tend to be driven by oxidative stress.

Enrollment: 70 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• 1-Forty subjects of COPD who are non-smokers or stopped smoking for more than 6 months Based on the Global Initiative for Chronic Obstructive Lung Disease guidelines, COPD was diagnosed.9 2- Thirty subjects of non smokers healthy control

Exclusion criteria

• Patients of:

  1. Acute exacerbation, at the time of the study, of COPD.
  2. Any obvious abnormal lung parenchymal lesions.
  3. Lung cancer.
  4. Congestive heart failure.
  5. current smokers
  6. Drugs e.g anti-inflammatory , steroids ,analgesics, insulin , antineoplastic, antipsychotic drugs in the previous 2 weeks before the study.

Trial design

70 participants in 2 patient groups

nonsmokers copd cases ,

Description:

Fourty subjects of COPD who are non-smokers or stopped smoking for more than 6 months

Treatment:

Other: oxidative stess markers

non smokers healthy control

Description:

Thirty subjects of non smokers healthy control

Treatment:

Other: oxidative stess markers