OxIGen: Oxford Imagery Generation: Investigating the Effects of an Internet Based Computer Program in Depression

University of Oxford

Status and phase: Completed; Phase 2

Conditions: Depression

Treatments: Other: OxIGen; Other: OxIGen: control version

Study type: Interventional

Funder types: Other

Identifiers

NCT01443234

11/SC/0278

Details and patient eligibility

About

This research study is designed to investigate the effects of an online computer program, called OxIGen (Oxford Imagery Generation), on thinking style and mood in depression. The OxIGen program will be delivered online over four weeks and with follow-up at one, three and six months. This will inform potential future development of this computerized task into an online intervention to modify negative thinking styles in depression.

Enrollment: 150 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Willing and able to give consent to the study
• Male or Female, aged between 18 and 65 years
• Current Major Depressive Episode (assessed by semi-structured clinical interview)
• Access to internet in order to complete the online program
• Able to travel to research centre for assessment appointments
• Fluent in written and spoken English

Exclusion criteria

• Meets criteria for current psychotic disorder
• History of mania or hypomania as assessed by semi-structured clinical interview, or has elsewhere received a diagnosis of Bipolar disorder
• Antidepressant medication begun or changed in dosage during last month
• Meets criteria for current substance abuse disorder
• Involved in other current treatment trials
• Currently receiving psychological therapy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

150 participants in 2 patient groups, including a placebo group

OxIGen program

Experimental group

Description:

Internet based intervention taking place over 4 weeks

Treatment:

Other: OxIGen

OxIGen: control version

Placebo Comparator group

Description:

A control version of the internet-based OxIGen intervention

Treatment:

Other: OxIGen: control version