Oxygen Extraction-guided Transfusion in Critically Ill Patients

Università degli Studi di Ferrara

Status: Completed

Conditions: Anemia; Critical Illness

Study type: Observational

Funder types: Other

Identifiers

NCT03767127

OEDT

Details and patient eligibility

About

Anemia is common in intensive care unit (ICU) patients and often appears early in the ICU course. The optimal management red blood cells RBC transfusion in critically ill patients remains controversial and clinical studies in this field have usually been based on transfusion thresholds. In the "TRICC" Trial, patients assigned to a restrictive transfusion strategy (transfusion if Hb<7 g/dL) had similar mortality to patients transfused if Hb<10 g/dL. Notably, none of the large RCT tried to focus on a personalize RBC transfusion protocol, i.e. a transfusion protocol which address the individual need for transfusion basing on physiological approach. We therefore hypothesized that patients with high extraction of oxygen could benefit more of RBCs transfusion regardless their hemoglobin levels.

Enrollment: 177 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Hemoglobin level <10 g/dL during the first 72 hours of ICU

Exclusion criteria

• Acute bleeding
• Hemoglobin level less than 7 g/dL

Trial design

177 participants in 2 patient groups

Appropriate transfusion policy

Description:

Patients transfused with high arterial-venous oxygen difference (≥3.7 ml/dl) or non-transfused with low arterial-venous oxygen difference (\<3.7 ml/dl)

Non-Appropriate transfusion policy

Description:

Patients transfused despite low arterial-venous oxygen difference or non-transfused with high arterial-venous oxygen difference