Oxygen Reserve Index to Reduce Hyperoxia

Eunah Cho, MD

Status: Completed

Conditions: Hyperoxemia

Treatments: Procedure: Titration of fraction of inspired oxygen (FiO2) guided by SpO2; Procedure: Titration of fraction of inspired oxygen (FiO2) guided by ORI and SpO2

Study type: Interventional

Funder types: Other

Identifiers

NCT04211246

2019-12-027

Details and patient eligibility

About

Excessive oxygen administration is known to cause oxidative stress, and absorption atelectasis. Hyperoxia is very common in general anesthesia settings. Even though there are concerns in using excessive oxygen during general anesthesia, the optimal fraction of inspired oxygen (FiO2) for general anesthesia is not well studied.

The oxygen reserve index (ORI) is a parameter which can evaluate partial pressure of oxygen (PaO2) rating from 0 to 1. There are growing evidences in ORI that it might be helpful to reduce hyperoxia in critically ill patients in the intensive care unit, as well as in general anesthesia.

The aim of this study is to evaluate efficacy of oxygen reserve index to reduce hyperoxemia in major abdominal surgery.

Enrollment: 64 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients scheduled for elective major abdominal surgery expected to last more than 2hours.
• Patients who are scheduled for invasive arterial cannulation during surgery.

Exclusion criteria

• Abnormal pulmonary function test
• Pregnancy
• Saturation of oxygen (SpO2) is below 92% in room air

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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64 participants in 2 patient groups

Standard group

Active Comparator group

Description:

Fraction of inspired oxygen (FiO2) is titrated guided by SpO2.

Treatment:

Procedure: Titration of fraction of inspired oxygen (FiO2) guided by SpO2

ORI group

Experimental group

Description:

Fraction of inspired oxygen (FiO2) is titrated guided by SpO2 and ORI

Treatment:

Procedure: Titration of fraction of inspired oxygen (FiO2) guided by ORI and SpO2