Oxygenation by 100% Oxygen Via High Flow Nasal Cannula in Surgical Patients

Karolinska University Hospital

Status: Completed

Conditions: Ventilation; Anaesthesia, General; Anesthesia, Intravenous

Treatments: Procedure: Hyperventilation

Study type: Interventional

Funder types: Other

Identifiers

NCT02706431

Apnoic Oxygenation

Details and patient eligibility

About

Oxygenation with high-flow nasal cannula with 100% oxygen has only been evaluated in a limited number of studies. Although data are convincing it is of importance to evaluate this new concept in our department before implementing it into clinical practice.

The general purpose of this project is to evaluate a new ventilation strategy during ENT-surgery based on oxygenation with high-flow nasal cannula with 100% oxygen with focus on gas exchange.

Enrollment: 31 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Adult, >18 years old
2. ENT-surgery where apnea is of benefit for the surgeon (eg. intraoral or laryngeal surgery) and the anesthesia time is <40 mins.
3. Capable of understanding the study information and sign the written consent.

Exclusion criteria

1. ASA>2
2. NYHA >2
3. BMI >30
4. Pregnancy
5. Manifest cardiac failure or coronary disease
6. Neuromuscular disease

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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31 participants in 2 patient groups

Normoventilation

No Intervention group

Description:

The patients will be normoventilated before anesthesia

Hyperventilation

Experimental group

Description:

Prior to anesthesia, the patients will hyperventilate during 2 mins or until symptoms from the central nervous system (e.g. dizziness).

Treatment:

Procedure: Hyperventilation