Oxygenation in Vascular Lesions of the Colon

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The University of Chicago

Status

Enrolling

Conditions

Vascular Lesion

Treatments

Other: Oxygen saturation

Study type

Interventional

Funder types

Other

Identifiers

NCT06230731
IRB23-1273

Details and patient eligibility

About

The goal of this clinical trial is to evaluate oxygenation in the colon in people with acquired vascular abnormalities in the proximal colon.

Full description

The etiology of acquired vascular abnormalities of the large bowel (i.e. angiodysplasia, AVM, hemangiomas of the cecum. etc.) are unknown. These lesions typical appear as ectatic, dilated, and tortuous blood vessels within the submucosa and mucosa of the GI tract. In some patients they are the cause of acute large volume bleeding or a slower chronic bleed that manifests as chronic iron deficiency anemia. These lesions are more common in older individuals and those with underlying cardiac, pulmonary, and renal disease. As such, it is hypothesized that these lesions may result from chronic hypoxia. This study aims to evaluate oxygenation of the colon in people with acquired vascular abnormalities in the proximal colon compared to healthy controls.

Enrollment

30 estimated patients

Sex

All

Ages

18 to 89 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Undergo standard of care colonoscopy
  • People with a history of vascular lesions of the colon
  • People with healthy colon
  • 18 - 89 years of age

Exclusion criteria

  • Age < 18 years
  • Age > 90 years
  • People with ulcerations in at ascending colon opposite the ileocecal valve
  • Previous colon surgery

Trial design

Primary purpose

Screening

Allocation

Non-Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

30 participants in 2 patient groups

Vascular abnormality group
Experimental group
Description:
People with acquired vascular abnormalities in the proximal colon
Treatment:
Other: Oxygen saturation
Control group
Active Comparator group
Description:
People with healthy colon
Treatment:
Other: Oxygen saturation

Trial contacts and locations

1

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Central trial contact

Joel Pekow, MD; Kristi Kearney, RN

Data sourced from clinicaltrials.gov

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