Oxyntomodulin, Mechanisms of Action in Relation to Appetite, Food Intake, Gastric Emptying and Energy Expenditure.

University Hospital, Gentofte, Copenhagen

Status: Completed

Conditions: Incretin Action; Obesity

Treatments: Other: GLP-1 and glucagon infusion; Other: Glucagon infusion; Other: Oxyntomodulin infusion; Other: GLP-1 infusion; Other: Placebo

Study type: Observational

Funder types: Other

Identifiers

NCT01232244

OXMDissek

Details and patient eligibility

About

Tiny molecules (hormones) are released from the bowels and other organs to the bloodstream in response to meals in order to orchestrate the metabolism. Oxyntomodulin, GLP-1 and glucagon are all known to regulate parameters such as appetite, food intake and induce weight loss.

Therefore we want to investigate mechanistic relations between the three hormones.

Enrollment: 15 patients

Sex: Male

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Normal fasting plasma glucose
• Normal glucose tolerance
• Normal haemoglobin levels
• Informed content

Exclusion criteria

• Diabetes
• Pre diabetes (impaired glucose tolerance or impaired fasting glucose)
• 1st degree relatives with diabetes
• Obesity (BMI > 30)
• Inflammatory bowels disease
• Bowels surgery
• Nephropathy
• Liver disease
• Medication which cannot be on hold for 24h

Trial design

15 participants in 1 patient group

Healthy young males

Treatment:

Other: GLP-1 infusion

Other: Glucagon infusion

Other: Placebo

Other: GLP-1 and glucagon infusion

Other: Oxyntomodulin infusion