Oxytocin and Eating

Yale-NUS College

Status and phase

Unknown

Phase 2

Conditions

Weight Gain

Treatments

Drug: Syntocinon

Drug: Placebos

Study type

Interventional

Funder types

Other

Identifiers

NCT03225456

IG15-LR052

Details and patient eligibility

About

In this protocol, the investigators propose a randomised controlled trial to explore the effects of intra-nasal oxytocin administration on appetite regulation. The investigators will run a cross-over design with 60 healthy adult men.

Enrollment

60 estimated patients

Sex

Male

Ages

21 to 45 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Gender: Male
Age: 21-45 years
Normal weight: Body mass index of 18.5 to 22.9
Have had a stable weight for the past 3 months (less than 5kg)
Have regular breakfast meals (≥ 4 times a week of self-reported consumption of a breakfast meal)
Have habitual sleep of 6.5-8.5 hours
Have English as first language (or fluent in spoken and written English)

Exclusion criteria

Symptoms / history of any major medical condition, including:
- Bariatric surgery or surgical obesity treatment
- Diabetes
- Cardiovascular disease
- Thyroid disease
- Anaemia
- Psychiatric disorders
- Eating disorders
Excessive exercise (running > 40 km or exercising > 10 hr in a week)
Currently on a special diet or trying deliberately to restrict food intake
Currently on a weight loss program
Smoking or substance abuse
Use of medications that can affect weight (e.g., steroids, approved weight-loss drugs)