Oxytocin and Emotion Processing

University Hospital Bonn (UKB)

Status and phase: Completed; Phase 1

Conditions: Healthy Males

Treatments: Drug: Oxytocin

Study type: Interventional

Funder types: Other

Identifiers

NCT02156661

OXT-FC-14

Details and patient eligibility

About

The purpose of this study is to determine whether oxytocin influences emotional processing and learning of emotional and social stimuli.

Full description

An effect of OXT on emotion processing and anxiety has been broadly investigated in animal studies. However, in humans, effects seem more complex.

The rationale of the study is to examine direct effects of OXT to processing and learning of emotional and social values in humans.

Enrollment: 97 patients

Sex: Male

Ages: 20 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy male volunteers

Exclusion criteria

• Current or past psychiatric disease
• Current or past physical illness
• Psychoactive medication
• Tobacco smokers
• MRI contraindication

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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97 participants in 2 patient groups, including a placebo group

Oxytocin

Active Comparator group

Description:

Oxytocin: Syntocinon-Spray, Novartis intranasal administration, 24 IU oxytocin; ; 3 puffs per nostril, each with 4 IU OXT

Treatment:

Drug: Oxytocin

Placebo

Placebo Comparator group

Description:

Placebo nasal spray

Treatment:

Drug: Oxytocin