Oxytocin and Incitement to Use Olfactory Stimuli in Restrictive Anorexia Nervosa

Fondation Lenval

Status: Completed

Conditions: Anorexia

Treatments: Other: No intervention; Other: other workshop; Other: olfactory workshop

Study type: Interventional

Funder types: Other

Identifiers

NCT02333500

14-AOI-06

Details and patient eligibility

About

This prospective pilot study will compare adolescents with restrictive anorexia nervosa who participated for 3 months at olfactory workshops, patients who did not, and healthy patients.The groups will be evaluated before the workshops and after three months, with the wanting score after olfactory stimuli and with serum oxytocin level.

Full description

The restrictive anorexia nervosa (AN) in adolescents is an eating disorder with decreased desire to eat (wanting) following olfactory stimulation. Oxytocin is an hormone involved in the neuromodulation of eating behavior, but also involved in olfactory perception in schizophrenia patients, and in social cognition in patients with autism. Its plasma level was found low in anorexic patients compared to control subjects.

Because of the similarity in disorders of social cognition between these three diseases, we assume that the desire to eat evoked by olfactory perception varies with the plasma oxytocin levels.

With a prospective pilot study we will compare patients with AN who participated for 3 months at olfactory workshops, AN patients who did not, and healthy patients.

The groups will be evaluated before the workshops and after three months, with the wanting score after olfactory stimuli and with serum oxytocin level.

One application of this study will be the use of ocytocyne nasal spray to increase the eating desire and to allow weight regain

Enrollment: 30 patients

Sex: All

Ages: 11 to 18 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Medical-Review
• Female or male -Sexe,
• 11 to 18 years
• Anorexia nervosa diagnosed according to the criteria DSM V
• Outpatient care or hospitalization
• Be able to answer the clinicals evaluations questionnaires
• Affiliated to social security
• Consentement of the legal representative and the patient

Exclusion criteria

• Somatic comorbidity associated with diabetes, celiac disease, brain tumor
• Intolerance odors, predisposed to develop asthma and / or respiratory allergies Pathologie chronic rhino-sinus
• Hyposmiques or anosmic
• Patients not of an inclusion criteria

Trial design

Primary purpose: Health Services Research

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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30 participants in 3 patient groups

olfactory workshop

Experimental group

Description:

Influence of sensory therapy on the rate of oxytocin

Treatment:

Other: olfactory workshop

other workshop

Active Comparator group

Description:

Influence of other workshop on the rate of oxytocin

Treatment:

Other: other workshop

control group

Other group

Description:

Rate of oxytocin of the control group

Treatment:

Other: No intervention