Oxytocin Effect on Attention Inhibition

University of Electronic Science and Technology of China

Status: Completed

Conditions: Healthy

Treatments: Drug: placebo treatment; Drug: oxytocin treatment

Study type: Interventional

Funder types: Other

Identifiers

NCT03486925

UESTC-neuSCAN-45

Details and patient eligibility

About

Effects of intranasal oxytocin (24IU) on cognitive control of attention

Full description

The cognitive control of attention towards neutral and emotional stimuli represents a key functional domain and disruptions in this domain have been associated with a range of psychiatric disorders. Saccadic eye movement tasks have been used to assess individual differences in the cognitive control of attention and alterations in psychiatric disorders. Recent evidence suggests that the hypothalamic neuropeptide Oxytocin (OXT) may modulate attention allocation and regulation. To this end the present randomized between-subject placebo-controlled experiment examined whether intranasal OXT modulates behavior in an eye-tracking saccade / anti-saccade paradigm in healthy male subjects. The paradigm used non-social (neutral shape) as well as social (happy, sad, angry, fear, and neutral faces) stimuli to explore emotion-specific effects of OXT.

Enrollment: 71 patients

Sex: Male

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Male, healthy participants
• Non smokers

Exclusion criteria

• Previous or current medical, psychiatric, neurological disorder
• Regular medication
• Use of any psychoactive substances in the 24 hours before experiment
• Contra-indications for oxytocin
• Contra-indications for eye-tracking data acquisition

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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71 participants in 2 patient groups, including a placebo group

oxytocin group

Experimental group

Treatment:

Drug: oxytocin treatment

placebo group

Placebo Comparator group

Treatment:

Drug: placebo treatment