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Oxytocin Effect on Attention Inhibition

U

University of Electronic Science and Technology of China

Status

Completed

Conditions

Healthy

Treatments

Drug: placebo treatment
Drug: oxytocin treatment

Study type

Interventional

Funder types

Other

Identifiers

NCT03486925
UESTC-neuSCAN-45

Details and patient eligibility

About

Effects of intranasal oxytocin (24IU) on cognitive control of attention

Full description

The cognitive control of attention towards neutral and emotional stimuli represents a key functional domain and disruptions in this domain have been associated with a range of psychiatric disorders. Saccadic eye movement tasks have been used to assess individual differences in the cognitive control of attention and alterations in psychiatric disorders. Recent evidence suggests that the hypothalamic neuropeptide Oxytocin (OXT) may modulate attention allocation and regulation. To this end the present randomized between-subject placebo-controlled experiment examined whether intranasal OXT modulates behavior in an eye-tracking saccade / anti-saccade paradigm in healthy male subjects. The paradigm used non-social (neutral shape) as well as social (happy, sad, angry, fear, and neutral faces) stimuli to explore emotion-specific effects of OXT.

Enrollment

71 patients

Sex

Male

Ages

18 to 30 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Male, healthy participants
  • Non smokers

Exclusion criteria

  • Previous or current medical, psychiatric, neurological disorder
  • Regular medication
  • Use of any psychoactive substances in the 24 hours before experiment
  • Contra-indications for oxytocin
  • Contra-indications for eye-tracking data acquisition

Trial design

Primary purpose

Basic Science

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

71 participants in 2 patient groups, including a placebo group

oxytocin group
Experimental group
Treatment:
Drug: oxytocin treatment
placebo group
Placebo Comparator group
Treatment:
Drug: placebo treatment

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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