Oxytocin Effects on Likeability After Being Liked or Disliked

University of Electronic Science and Technology of China

Status: Completed

Conditions: Social Behavior

Treatments: Drug: Oxytocin; Drug: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT02745431

UESTC-neuSCAN-06

Details and patient eligibility

About

The current study aimed to investigate oxytocin effect on the response after the experience of being liked or disliked.

Full description

In a double-blind, between-subject, placebo controlled design study, the researchers aimed to investigate the intranasal OXT (40IU) treatment on rating response after being liked or disliked in healthy male subjects. All subjects completed a range of questionnaires measuring personality and affective traits and levels of anxiety: Positive and Negative Affect Schedule (PANAS) , State-Trait Anxiety Inventory (STAI) , Beck Depression Inventory (BDI), Cheek and Buss shyness Scale (CBSS),Autism Spectrum Quotient (ASQ), Empathy Quotient(EQ) before self-administration.Study participants were led to believe that other participants had formed an opinion on their likability based on their appearance in a photograph and they passively viewed the responses (like or dislike) from 'other participants'. After that, they rated 'other participants' about likeability (how much do you like the person), accuracy (have you seen the person), feeling (how good do you feel), and tendency (how much would do like have him/her as a friend). Likeability, tendency, feeling and accuracy were included into analysis as dependent variables.

Enrollment: 86 patients

Sex: Male

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy subjects without past or current psychiatric or neurological disorder

Exclusion criteria

• history of head injury;
• claustrophobia;
• medical or psychiatric illness.

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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86 participants in 2 patient groups, including a placebo group

Oxytocin nasal spray

Experimental group

Description:

Oxytocin nasal spray

Treatment:

Drug: Oxytocin

Placebo nasal spray

Placebo Comparator group

Description:

Placebo nasal spray

Treatment:

Drug: Placebo