Oxytocin Effects on the Prosocial Learning

University of Electronic Science and Technology of China

Status: Completed

Conditions: Healthy

Treatments: Drug: Placebo; Drug: Oxytocin

Study type: Interventional

Funder types: Other

Identifiers

NCT04105140

UESTC-neuSCAN-44

Details and patient eligibility

About

To investigate whether intranasal oxytocin (24 IU) treatment can influence prosocial learning behavior in males.

Full description

In a double-blind, within-subject, placebo controlled design, investigators plan to investigate the effect of oxytocin treatment on prosocial learning. Before the self-administration, participants need to finish several questionnaires including IRI, AAS, BASBIS, SPSRQ, SES, PTM, STAI, BDI, ASQ and PNAS. They would finish the PANAS again before the scanning.

Participants are informed that they perform the reward learning task either for themselves, another (unknown) person or no one (control). In the probabilistc reward learning task, associations with two stimuli with different reward probabilities are learned via monetary feedback (reward ￥1 or no reward ￥0). After the experiment, participants need to finish the PANAS.

Enrollment: 90 patients

Sex: Male

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• without past or current psychiatric or neurological disorders

Exclusion criteria

• history of head injury
• medical or psychiatric illness

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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90 participants in 2 patient groups, including a placebo group

male oxytocin group

Experimental group

Description:

male subjects with oxytocin treatment

Treatment:

Drug: Oxytocin

male placebo group

Placebo Comparator group

Description:

male subjects with placebo treatment

Treatment:

Drug: Placebo