Oxytocin's Effect on the Advantageous- and Disadvantageous-inequity

University of Electronic Science and Technology of China

Status: Completed

Conditions: Healthy

Treatments: Drug: Intranasal oxytocin; Drug: Intranasal placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT06405737

UESTC-neuSCAN-88

Details and patient eligibility

About

The main aim of the study is to investigate whether intranasal oxytocin modulates advantageous- and disadvantageous-inequity and whether oxytocin has similar effects on them or not.

Full description

The main aim of the study is to investigate whether intranasal oxytocin modulates advantageous- and disadvantageous-inequity and its underlying neural mechanisms and whether oxytocin has similar effects on them or not. A double-blinded, placebo-controled, between-subject design is employed in this study. In a randomized order, a total of 80 healthy males are instructed to self-administrated intranasal spray of oxytocin or placebo. A modified inequity decision-making task starts 45 minutes after treatment with behavioral (fairness rating, preference rating and the choice rate of unequal option) and fMRI data being collected during this task. Personality traits of subjects are assessed using validated Chinese version questionnaires including the Beck Depression Inventory (BDI-II), State-Trait Anxiety Inventory (STAI), Autism Spectrum Quotient (ASQ), Sensitivity to Punishment and Sensitivity to Reward Questionnaire (SPSRQ), Behavioral Inhibition System and Behavioral Activation System Scale (BIS/BAS). Subjects are asked to complete Positive and Negative Affect Schedule (PANAS) when they just arrive, before and after the task.

Enrollment: 80 patients

Sex: Male

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy subjects without past or current psychiatric or neurological disorders

Exclusion criteria

• history of head injury
• pregnant,menstruating,taking oral contraceptives
• medical or psychiatric illness.
• excessive head movement (> 3mm) during scanning

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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80 participants in 2 patient groups

oxytocin

Experimental group

Description:

a single dose of 24 international units (IU) of OT will be administered with 3 puffs of treatment to each nostril.

Treatment:

Drug: Intranasal oxytocin

placebo

Experimental group

Description:

a single dose of 24 international units (IU) of placebo will be administered with 3 puffs of treatment to each nostril.

Treatment:

Drug: Intranasal placebo