Oxytocin's Effects on Face Attentional Processing

University of Electronic Science and Technology of China

Status: Completed

Conditions: Healthy

Treatments: Drug: placebo treatment; Drug: oxytocin treatment

Study type: Interventional

Funder types: Other

Identifiers

NCT04413786

UESTC-neuSCAN-71

Details and patient eligibility

About

To investigate whether intranasal oxytocin (24IU) treatment has a regulatory effect on attentional processing of emotional faces.

Full description

In a placebo-controlled double-blind between-subject design experiment, investigators plan to investigate the effect of oxytocin treatment on attentional processing of emotional faces. Subjects complete questionnaires in Chinese versions before treatment administration, including the Beck Depression Inventory, Autism Spectrum Quotient , Trait Anxiety Inventory, Toronto Alexithymia Scale, Multidimentional Assessment of Interoceptive Awareness. This experiment consists of two tasks including Emotional Face Cue-target Task and Visual Search Task. In the first task, subjects need to make a response to judge the position of target after a cue-target is presented. In the second task, subjects are asked to search the target "U" or inverted "U" placed on the nose of emotional/neutral faces and make an choices based on their oorientation. During these phases, subjects' response accuracy, response time and electrophysiological activity (ERP) are recorded.

Enrollment: 60 patients

Sex: Male

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy subjects without past or current psychiatric or neurological disorders.

Exclusion criteria

• history of head injury
• medical or psychiatric illness

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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60 participants in 2 patient groups, including a placebo group

oxytocin group

Experimental group

Description:

male subjects with oxytocin treatment

Treatment:

Drug: oxytocin treatment

placebo group

Placebo Comparator group

Description:

male subjects with placebo treatment

Treatment:

Drug: placebo treatment