Ozone Application in Periodontal Treatment

Biruni University

Status: Enrolling

Conditions: Periodontitis

Treatments: Procedure: Non-surgical periodontal treatment; Device: Ozone therapy using a device (Ozone DTA Ozone Generator, Denta Tec Dental AS, Norway)

Study type: Interventional

Funder types: Other

Identifiers

NCT05971706

Ozone

Details and patient eligibility

About

This clinical trial aims to evaluate the clinical, biochemical and microbiological efficacy of ozone treatment as an adjunct to nonsurgical periodontal treatment (NSPT) in periodontitis patients. The main question it aims to answer is:

• Is the application of gaseous ozone, as an adjunct to NSPT, to periodontal pockets in patients with periodontitis alters the clinical periodontal parameters, gingival crevicular fluid levels of inflammatory cytokines, and periodontal pathogens compared to NSPT alone? The study will be performed according to a split-mouth design, the contralateral quadrants with similar periodontal status in each patient will be randomly allocated to one of the following two different treatment modalities.

Participants will be applied NSPT consisting of supra and subgingival debridement.

• NSPT will be applied alone in one quadrant
• In addition to NSPT, ozone therapy procedures were performed using a device at contralateral sites.

Researchers will compare the sites with and without ozone therapy in addition to NSPT to see if ozone therapy adjunct to the NSPT affects clinical, biochemical, and microbiological changes

Enrollment: 18 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• systemically healthy
• no periodontal treatment within 6 months from the enrollment date
• no antibiotics or anti-inflammatory medication taken within 6 months from the enrollment date
• no smokers
• no pregnancy or lactation at the time of the stud
• no contraindication for periodontal treatment and ozone application

Exclusion criteria

• Participants will be excluded if they had less than 20 teeth, partial dentures, or fixed prosthodontics.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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18 participants in 2 patient groups

ozone

Experimental group

Description:

Gaseous ozone was applied immediately after non-surgical periodontal treatment

Treatment:

Procedure: Non-surgical periodontal treatment

Device: Ozone therapy using a device (Ozone DTA Ozone Generator, Denta Tec Dental AS, Norway)

control

Active Comparator group

Description:

Only non-surgical periodontal treatment was applied

Treatment:

Procedure: Non-surgical periodontal treatment