Ozone Therapy for the Treatment of Oral Mucositis in Patients Undergoing Radio and Chemotherapy in the Head and Neck Region

Andrea Scribante

Status: Completed

Conditions: Oral Mucositis; Head and Neck Neoplasms

Treatments: Device: Ozone treatment

Study type: Observational

Funder types: Other

Identifiers

NCT07247799

2025-OZONEMUCOSITIS

Details and patient eligibility

About

The present study aims to evaluate the effectiveness of a combined protocol of professional and at-home ozone therapy in the treatment of oral mucositis in patients undergoing radio- and/or chemotherapy.

In-office treatment was performed using a medical ozone generator, while at-home therapy involved the daily application of high-concentration ozonated oil products. The study assessed the reduction in mucositis severity (WHO scale), decrease in pain (VAS scale), and improvement in patient-reported quality of life, with specific attention to nutrition, oral hygiene, and treatment adherence.

Enrollment: 38 patients

Sex: All

Ages: 40 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients undergoing radio and chemotherapy for head and neck cancer and cancers in other districts

Exclusion criteria

• syndromic patients
• pregnant women
• patients with cardiac pacemakers
• epileptic patients
• patients with high sensitivity to electric current

Trial design

38 participants in 2 patient groups

Patients undergoing radio and chemotherapy for head and neck cancer

Treatment:

Device: Ozone treatment

Patients undergoing radio and chemotherapy for cancers in other districts

Treatment:

Device: Ozone treatment