Ozone Therapy in Endodontic Practice, in Vivo Study

University of Sao Paulo

Status and phase: Completed; Phase 2

Conditions: Primary Apical Periodontite

Treatments: Drug: Ozone; Drug: Control (no last irrigation); Drug: Aqueous Ozone

Study type: Interventional

Funder types: Other

Identifiers

NCT00946634

CEP 154/06

Details and patient eligibility

About

The ozone therapy has been coming up as a new therapeutic modality. Medicine has been practicing since XIX century and counted great results. It is indicated for the treatment of 260 different pathologies. The researches in Dentistry has showed promising results, indicating a wide spread action in whole dental specialties. The great oxidative power of ozone provides a great antimicrobial effect and it increases the adenosine triphosphate (ATP) synthesis that can be considered as a general improvement of the cell metabolism, which can potentize the repair process. Thus, these facts justify the present study which will assess the increase of speed of apical periodontite repair.

Enrollment: 60 estimated patients

Sex: All

Ages: 13 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy patients
• Radiographic evidence of apical periodontite
• No previous root canal treatment

Exclusion criteria

• Unhealthy patients
• Regular response to sensibility test
• Previous root canal treatment

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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60 participants in 3 patient groups

Ozone Gas

Experimental group

Description:

Endodontic protocol preconized by University of Sao Paulo associated to ozone gas 40 mg/L

Treatment:

Drug: Ozone

Control

Active Comparator group

Description:

Regular endodontic protocol preconized by University of Sao Paulo

Treatment:

Drug: Control (no last irrigation)

Aqueous Ozone

Experimental group

Description:

Endodontic protocol preconized by University of Sao Paulo associated to Aqueous ozone 40mg/L

Treatment:

Drug: Aqueous Ozone