p-AKT Expression on Clinical Outcomes in Malignant Lymphoma

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Samsung Medical Center

Status

Completed

Conditions

Malignant Lymphoma
P13K-AKT Pathway Deregulation

Treatments

Other: p-AKT immunohistochemical staining

Study type

Observational

Funder types

Other

Identifiers

NCT01789060
2013-01-047

Details and patient eligibility

About

PI3K(phosphatidylinositol 3-kinase)/AKT pathway is an important oncogenic signaling pathway. However, clinical information about the significance of p-AKT expression in malignant lymphoma is not fully understood yet. In this study, we investigated the overexpression of p-AKT and its prognostic implication in malignant lymphoma.

Full description

Recently, among diverse oncogenic signaling pathways, a number of studies have focused on the significance of oncogenic PI3K/AKT (phophatidylinositol 3-kinase/serine-threonine kinase, also known as protein kinase B [PKB]) pathway. PI3K(phosphatidylinositol 3-kinase)/AKT pathway phosphorylates and activates AKT as phosphorylated AKT (p-AKT) and plays a critical role promoting malignant phenotype and has prognostic significance in various solid cancers. However, a systematic approach on the impact of p-AKT overexpression on clinical outcomes has not been performed in malignant lymphoma.

Enrollment

262 patients

Sex

All

Ages

17 to 90 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  1. the patients were pathologically confirmed of malignant lymphoma, according to the World Health Organization classification;
  2. the patients had adequate paraffin-embedded biopsy specimen or unstained slides for immunostaining of p-AKT.

Exclusion criteria

  1. Primary central nervous system lymphoma was excluded in this study

Trial design

262 participants in 1 patient group

p-AKT
Description:
p-AKT immunohistochemical staining,high p-AKT expression (upper quartile), low p-AKT expression (lower 3 quartiles)
Treatment:
Other: p-AKT immunohistochemical staining

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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