P. Gingivalis IgG Titer Test for Periodontitis

Okayama University

Status: Completed

Conditions: Periodontitis

Study type: Observational

Funder types: Other

Identifiers

NCT01658475

JSPS #18209061 & H19-Choju-008 (Other Grant/Funding Number)

OUGSMDPS-350&453

Details and patient eligibility

About

This study was performed to evaluate prospectively the diagnostic utility of a blood IgG antibody titer test against periodontal pathogens.

Full description

Background: Periodontitis is a prevalent silent infectious disease worldwide, and affects lifestyle-related diseases such as diabetes. Therefore, efficient screening of patients is essential for general health. This study was performed to evaluate prospectively the diagnostic utility of a blood IgG antibody titer test against periodontal pathogens.

Methods: Oral examination was performed and blood IgG antibody titers against periodontal pathogens were measured by ELISA, in 1387 subjects. The cut-off value of IgG titer was determined in receiver operating characteristic curve analysis, and changes in periodontal clinical parameters and IgG titers by periodontal treatment were evaluated. The relationships between IgG titers and severity of periodontitis were analyzed.

Enrollment: 1,387 patients

Sex: All

Ages: 20+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• periodontal patients
• adults

Exclusion criteria

• difficulty of communication
• received periodontal therapy within 3 months
• with other diseases, i.e., hypertension, diabetes (self reported)

Trial design

1,387 participants in 1 patient group

periodontitis

Description:

those with periodontitis and those without periodontitis