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P-wave Duration and Dispersion in Intrahepatic Cholestasis of Pregnancy

Z

Zekai Tahir Burak Women's Health Research and Education Hospital

Status

Unknown

Conditions

Arrhythmia
Intrahepatic Cholestasis of Pregnancy

Study type

Observational

Funder types

Other

Identifiers

NCT01906827
zekai tahir burak- p wave

Details and patient eligibility

About

The bile acids has been demonstrated to cause arrhythmia and abnormal calcium dynamics in cultured neonatal rat cardiomyocytes. Bile acids may alter maternal cardiomyocyte function like fetus.Increased P-wave duration and P-wave dispersion have been reported in various clinical settings. The investigators hypothesized that PWD and p wave duration may affect in pregnancy with ICP.

Full description

Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disease. The most frequent laboratory abnormality is elevation of serum bile acid levels in ICP.

Bile acids increases both maternal and fetal circulation in ICP. The bile acids has been demonstrated to cause arrhythmia and abnormal calcium dynamics in cultured neonatal rat cardiomyocytes. Raised maternal bile acid levels have been associated with fetal distress and arrhytmia in fetus.

P-wave dispersion (PWD) is defined as the difference between the maximum and the minimum P-wave durations measured on a 12-lead surface electrocardiogram (ECG). Increased P-wave duration and PWD have been reported in various clinical settings, including atrial flutter, coronary artery disease, hypertension, rheumatic mitral stenosis, mitral annular calcification, obstructive sleep apnea, and obesity.

So the investigators think that bile acids may alter maternal cardiomyocyte function as fetus. The investigators hypothesized that PWD and p wave duration may affect in pregnancy with ICP.

The aim of this study is to investigate maternal P-wave duration and dispersion changes in pregnant women with intrahepatic cholestasis of pregnancy .

Enrollment

90 estimated patients

Sex

Female

Ages

18 to 39 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Pregnants who with ICP

Exclusion criteria

  • Chronic liver disease
  • Disease during current pregnancy
  • Multiple pregnancies

Trial design

90 participants in 1 patient group

pregnant with ICP
Description:
pregnant with ICP

Trial contacts and locations

1

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Central trial contact

ozgur kirbas, md; ayse kirbas, md

Data sourced from clinicaltrials.gov

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