P-wave Terminal Force in Patients With Atrial Fibrillation. (Ptf-AF)

Medical University of Lublin

Status: Unknown

Conditions: Atrial Fibrillation

Treatments: Procedure: cardioversion

Study type: Observational

Funder types: Other

Identifiers

NCT03428971

MW-MULublin-1

Details and patient eligibility

About

It is suggested that P-wave terminal force (Ptf), a product of the amplitude (PAM) and the duration (PT) of the terminal phase of P-wave in lead V1, shows early delay in left atrial conduction, observed earlier that the dilatation of left atrium.

The aim is to follow PT, PAM and Ptf changes during 5-year follow-up (5FU) and examine the relation of these changes to the number of AF episodes requiring hospitalisation (HOSP) for restoration of sinus rhythm (RSR).

Full description

Background. It is suggested that P-wave terminal force (Ptf), a product of the amplitude (PAM) and the duration (PT) of the terminal phase of P-wave in lead V1, shows early delay in left atrial conduction, observed earlier that the dilatation of left atrium.

Aim. We aim to follow PT, PAM and Ptf changes during 5-year follow-up (5FU) and examine the relation of these changes to the number of AF episodes requiring hospitalisation (HOSP) for restoration of sinus rhythm (RSR).

We hypothesise that, in patients with atrial fibrillation (AF):

1. the index parameters (PT, PAM, Ptf), characterising left atrial repolarization, correlates the number of future hospitalisations (HOSP) aimed for restoration of sinus rhythm (RSR) in 5-year follow-up (5FU)
2. in 5FU the number of HOSP aimed for RSR correlates with the progression of left atrium electrical remodelling, expressed as PAM5,PT5, Ptf5 at 5FU.

Enrollment: 600 estimated patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• documented atrial fibrillation at admission
• successful restoration of sinus rhythms documented in 12-leads ECG,
• follow-up => 5 years

Exclusion criteria

• arrhythmia other than atrial fibrillation at admission,
• unsuccessful restoration of sinus rhythms,
• successful restoration of sinus rhythms but missing 12-leads ECG recording,
• previous ablation/operation within left atrium,
• follow-up < 5 years