P300 in Early Cognitive Impairment in Hepatitis C Virus

Mansoura University Hospital

Status: Completed

Conditions: Cognitive Impairment; Hepatitis C

Treatments: Diagnostic Test: Visual Event-Related Potentials

Study type: Observational

Funder types: Other

Identifiers

NCT04389268

Mansoura University HCV

Details and patient eligibility

About

Approximately 50% of patients with hepatitis C have complaints of fatigue and cognitive deficits even before the development of significant hepatic impairment.

Full description

Assessing the influence of HCV infection on the development of cognitive changes involves many challenges. The frequent presence of confounding factors such as illicit drug use, depression, and cirrhosis has the potential to produce cognitive impairment and therefore obscuring the role of HCV infection as a major actor in the development of cognitive impairment.

The presence of brain dysfunction in patients with liver cirrhosis is well known. Zeegen et al. described in 1970, through the use of neuropsychological tests, the occurrence of cognitive changes involving mainly psychomotor speed, attention, and executive function in cirrhotics who did not have clinical criteria for hepatic encephalopathy. This condition is currently called minimal hepatic encephalopathy.

Enrollment: 100 patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Newly diagnosed HCV infection

Exclusion criteria

• Any neuropsychiatric disease that cause impaired cognition

Trial design

100 participants in 2 patient groups

HCV patients

Description:

Patients with uncomplicated newly diagnosed hepatitis C virus

Treatment:

Diagnostic Test: Visual Event-Related Potentials

Control group

Description:

Age and sex matched with patients

Treatment:

Diagnostic Test: Visual Event-Related Potentials