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Pituitary adenylate cyclase-activating polypeptide (PACAP) is a signaling molecule, localized in sensory and parasympathetic perivascular nerves fibres. PACAP exists i to functional iso-forms Pituitary adenylate cyclase-activating polypeptide-38 (PACAP38) and PACAP27.
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Inclusion criteria
Migraine patients meeting International Headache Society (IHS) criteria for migraine without aura of both sexes, 18-60 year, 50-100 kg.
Exclusion criteria
Tension Type headache for more than 5 days the month on average in the last year.
Hypertension (systolic blood pressure> 150 mmHg and / or diastolic blood pressure> 100 mmHg)
Hypotension (systolic blood pressure <90 mm Hg and / or diastolic blood pressure <50 mmHg)
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Interventional model
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20 participants in 2 patient groups, including a placebo group
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Data sourced from clinicaltrials.gov
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